"The Gastrointestinal Microbiome as a Marker of Disease Activity in Systemic Sclerosis"

Primary Investigators:
Elizabeth R. Volkmann, MD, MS 
Zsuzsanna McMahan, MD, MHS

"1000 minds SRC"

Primary Investigators:
Marie Hudson, MD, MPH
Christopher Denton, MD, PhD

"Spatial Frequency Domain Imaging as a New Method to Quantify Skin Changes in Scleroderma"

Primary Investigator:
Andreea M. Bujor, MD, PhD

"Developing a Systemic Sclerosis Patient Global Assessment"

Primary Investigators:
Laura Ross, MBBS, FRACP
John D. Pauling, PhD, FRCP

"The Effect of Orally Administered Pyrophosphate on Calcinosis Formation in Systemic Sclerosis"

Primary Investigators:
László Kovács, MD, PhD, DSc

"A Working Group on Limited Systemic Sclerosis to Select Candidate Items for the CRISTAL (Combined Response Index for Scleroderma Trials Assessing Limited SSc) Index"

Primary Investigators:
Dinesh Khanna, MD, MSc
Alain Lescoat, MD, PhD

"Ultrasound Based Outcome Measure of Soft Tissue Calcinosis in Scleroderma"

Primary Investigators:
Lorraine Green
Robert Fairchild

"Characterizing Clinical Features and Outcomes in Late Onset Scleroderma Renal Crisis: A Multi-Center Study"

Primary Investigators:
Swati Mehta

"Evaluating the Role of Vascular Endothelial Growth Factor (VEGF) and VEGF-Induced Osteoclast Activity in the Pathogenesis of Calcinosis in Systemic Sclerosis"

Primary Investigators:
Antonia Valenzuela, MD, MS
Claudia Huerta Calderon

"Development of SCTC Classification Criteria of Systemic Sclerosis Heart Involvement Using Consensus and Multi-Criteria Decision Analysis Methods"

Primary Investigators:
Mandana Nikpour, MBBS, FRACP, FRCPA, PhD
Murray Baron, BBS, MDCM, FRCP(C)
Alessandra Vacca, MD
Laura Ross, MBBS, FRACP

"Development of Preliminary Classification Criteria for Scleroderma Renal Crisis"

Primary Investigators:
Marie Hudson, MD, MPH
Christopher Denton, MD, PhD

"Evaluating the Role of Vascular Endothelial Growth Factor (VEGF) and VEGF-Induced Osteoclast Activity in the Pathogenesis of Calcinosis in Systemic Sclerosis"

Primary Investigator:
Antonia Valenzuela MD, MS

"Synchronizing Systemic Sclerosis Skin Gene Expression and Histology Data with a Machine Learning Approach"

Primary Investigator:
Kimberly Showalter, MD

"Development of Preliminary Classification Criteria for Scleroderma Renal Crisis"

Primary Investigators:
Marie Hudson, MD MPH and Christopher Denton, MD PhD

"Development of a Novel Patient-Reported Outcome Instrument for the Assessment of Digital Ulcers in Systemic Sclerosis"

Primary Investigators:
Michael Hughes, PhD MRCP
John Pauling, PhD FRCP

"Development of a Preliminary Definition of Systemic Sclerosis Heart Involvement"

Primary Investigators:
Mandana Nikpour, MBBS, FRACP, FRCPA, PhD
Murray Baron, BBS, MDCM, FRCP(C)
Dr. Alessandra Vacca

"Plasma Inorganic Pyrophosphate (PPi) Levels as a Biomarker for Ectopic Calcification in Scleroderma Spectrum and Other Rheumatic Diseases"

Primary Investigators:
Dr. Vivien Hsu
Dr. John Varga

"Development and Validation of a Novel Patient-Derived Patient-Reported Outcome Instrument for Assessing the Activity and Impact of Raynaud's Phenomenon in Systemic Sclerosis"

Primary Investigators:
John Pauling, BMedSci, BMBS, PhD, FRCP
Robyn T. Domsic, MD, MPH
Dinesh Khanna, MD, MS

"Development of a Consensus Definition for Scleroderma Renal Crisis (SRC)"

Primary Investigators:
Marie Hudson, MD, MPH
Christopher Denton, MD, PhD

"A Prospective Study to Identify Risk Factors for Progressive Calcinosis in Patients with Systemic Sclerosis: A Scleroderma Clinical Trials Consortium Study"

Primary Investigator:
Lorinda Chung, MD, MS

"Development of a Conceptual Framework for a Novel Patient-Reported Outcome Instrument for the Assessment of Digital Ulcers in Systemic Sclerosis"

Primary Investigators:
Michael Hughes, PhD, MRCP
John Pauling, PhD, FRCP

"The SCTC Damage Index: External Validation in the Canadian Scleroderma Research Group (CSRG) Cohort and Prospective Validation in the INternational SYstemic Sclerosis INception Cohort (INSYNC)"

Primary Investigators:
Mandana Nikpour, MB BS, FRACP, FRCPA, PhD
Murray Baron, BSc, MDCM, FRCP(C)